Effects of EGCG-Enhanced Extra Virgin Olive Oil on Endothelial Function

Study ID	NCT00865787
Status	Recruiting
Phase	-
Source	ClinicalTrials.gov

Started	Feb 1 2008
Last Updated	Sep 9 2009
Estimated Completion	Sep 9 2009

About this clinical study

Summary

This study is being done to determine if the use of EGCG-Enhanced Extra Virgin Olive Oil in a daily diet will improve endothelial function.

Condition / Disease

Atherosclerosis

Study Outcomes

Supplementation with enhanced olive oil will improve endothelial function as assessed by the reactive hyperemia peripheral arterial tonometry (RH-PAT) in patients with coronary artery disease (CAD) risk factors and endothelial dysfunction
Supplementation of EGCG enhanced olive oil will reduce peripheral markers of endothelial dysfunction and inflammation, oxidative stress and inflammation

Description

Patients will be randomized to receive either placebo ROO (refined olive oil) or study solution EGCG-EVOO (EGCG enhanced extra-virgin olive oil) over the four month study period.

Overview

Gender	male, female

Target Enrollment	50

Recruiting Healthy Volunteers	Yes

Locations

Mayo Clinic

Rochester

Criteria

Inclusion Criteria:

Patients will be included in the study if they have an abnormal endothelial function study. This is defined at our institution as an RH-PAT index of less than 2. Patients will undergo two RH-PAT analyses and included abnormal values are obtained on either one or both tests. Only patients who provide written informed consent will be included.